BCH 768
Comparative analysis of RNA structure
Lecture
materials |
 Slide show (7.5Mbyte PDF)
Handouts (7.5Mbyte PDF) |
Readings |
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Brown JW and Ellis JC, Comparative analysis of RNA secondary structure: 6S RNA, In Handbook of RNA Biochemistry, Wliley-VCH, Weinhein, 2005 pp 491-512
This is a recent 'hands-on' description of the initial stages of the comprative analysis of an RNA secondary structure. (11.8Mbyte PDF) |
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Michel F and Costa M, Inferring RNA structure by phylogenetic and genetic analysis. In RNA Structure and Function, CSH Laboratory Press, Cold Spring Harbor, NY. 1998 pp 175-202
This is an elderly review of the whole comparative approach, but focued on the intermediate state - the refinement of the secondary structure and the identification of higher-order structure. (2Mbyte PDF) |
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Massire C, Jaeger L and Westhof E 2008 Derivation of the three-dimensional architecture of bacterial ribonuclease P RNAs from comparative sequence analysis. J. Mol. Biol. 279:733-793
This is also an elderly paper, but a wonderful example of bringing everything together into a useful three-dimensional model. (3.8Mbyte PDF) |
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Last updated
March 04, 2009
by JWBrown
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